Halofuginone
Data Sheet
For research use only. Not for human use.
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| CAS No. | 55837-20-2 | Cat. No. | BCP07016 |
| Name | Halofuginone | ||
| Synonyms | Tempostatin;RU-19110;RU 19110;RU19110; | ||
| SMILES | C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O | ||
| Chemical Name | |||
| Formula | C16H17BrClN3O3 | M. Wt | 414.69 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Halofuginone, also known as RU-19110, is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. | ||
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