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MK-2206 Chemical Structure

MK-2206

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20200CAS No. :1032349-93-1Purity:98%
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  • Publications Citing of Biochempartner's MK-2206
  • Chemical Properties&Biological Activity
CAS No. 1032349-93-1 Cat. No. BCP20200
Related Products 1032350-13-2(MK-2206 2HCl)
Name MK-2206
Synonyms MK 2206;MK2206;
SMILES C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N
Chemical Name
Formula C25H21N5O M. Wt 407.48
Purity 98% Storage Store at 4-8°C
Description MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. It also inhibits tumor growth in animal models of nasopharyngeal cancer.
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