Gabexate mesylate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 56974-61-9 | Cat. No. | BCP13557 |
| Name | Gabexate mesylate | ||
| Synonyms | FOY;Gabexate Mesilate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H27N3O7S | M. Wt | 417.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0 degrees ), respectively. Gabexate mesylate inhibited the fibrinogenolytic activity of human tryptase. Gabexate Mesylate decreased the TNFalpha production of LPS-stimulated monocytes as shown by the inhibition of mRNA expression and increased the IL-10 production of LPS-stimulated monocytes. Gabexate Mesylate also suppressed the NFkappaB activity of LPS-stimulated monocytes. Inhibitory effect of Gabexate Mesylate on the TNFalpha production of activated human monocytes is mediated by the suppression of NFkappaB activation . Gabexate mesylate inhibits competitively constitutive and inducibl | ||
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