R406

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01933CAS No. ：841290-80-0Purity：98%

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CAS No.	841290-80-0	Cat. No.	BCP01933
Related Products	841290-81-1（R406 besylate）
Name	R406
Synonyms	R-406;R 406;R406 free base;Tamatinib;
SMILES
Chemical Name
Formula	C22H23FN6O5	M. Wt	470.45
Purity	98%	Storage	Store at 4-8°C
Description	R406 is an ATP-competitive inhibitor of Syk with a Ki value of 30 nM. R406 selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM, more potently than Syk-independent pathways in different cells.R406 inhibits cellular proliferation of a large panel of diffuse large B-cell lymphoma (DLBCL) cell lines at EC50 values ranging from 0.8 μM to 8.1 μM. R406 treatment (1 μM or 4 μM) induces the activation of caspases 9 and 3, but not caspase 8, leading to significant apoptosis of the majority of DLBCL cell lines. Pretreatment of R406 completely blocks the phosphorylation of SYK525/526 and the SYK-dependent phosphorylation of BLNK in R406-sensitive DLBCLs following B-cell receptor (BCR) crosslinking. R406 potently decreases MMP-9 mRNA levels by 2.8- and 4.3-fold lower than controls after 24 and 48 hours treatment, respectively, and reduces the invasive capacity of the RL cells.