BIBW2992 Dimaleate
Data Sheet
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| CAS No. | 850140-73-7 | Cat. No. | BCP08915 |
| Related Products | 439081-18-2（Afatinib） 850140-72-6（Afatinib） | ||
| Name | BIBW2992 Dimaleate | ||
| Synonyms | BIBW 2992MA2; BIBW-2992; BIBW2992; BIBW 2992; Afatinib; Afatinib dimaleate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C32H33ClFN5O11 | M. Wt | 718.08 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Afatinib dimaleate is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor. | ||
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