AZD-8931
Data Sheet
For research use only. Not for human use.
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| CAS No. | 848942-61-0 | Cat. No. | BCP02835 |
| Name | AZD-8931 | ||
| Synonyms | AZD8931;AZD 8931;Sapitinib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H25ClFN5O3 | M. Wt | 473.93 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD8931 shows different potency to NSCLC and SCCHN cell lines. AZD8931 has high sensitivity to PC-9 cells (EGFR activating mutation) with GI50 of 0.1 nM and low activity to NCI-1437 cells with GI50 above 10 μM. AZD8931 exhibits more potency against phospho-EGFR, phospho-erbB2 and phospho-erbB3 than either lapatinib or gefitinib in PE/CA-PJ41, PE/CA-PJ49, DOK and FaDu cells. | ||
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