GW2580

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06918CAS No. ：870483-87-7Purity：98%

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CAS No.	870483-87-7	Cat. No.	BCP06918
Name	GW2580
Synonyms	GW 2580;GW-2580;
SMILES
Chemical Name
Formula	C20H22N4O3	M. Wt	366.41
Purity	98%	Storage	Store at 4-8°C
Description	GW2580 completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 inhibits the growth of CSF-1 stimulated M-NFS-60 myeloid tumor cells, serum stimulated NSO myeloid tumor cells, CSF-1 stimulated freshly isolated human monocytes, and VEGF stimulated human umbilical vein vascular endothelial cells with IC50 of 0.33, 13.5, 0.47 and 12 μM, respectively. 1 μM GW2580 completely inhibits CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes and completely inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone. GW2580 inhibits CSF1R phosphorylation in RAW264.7 murine macrophages stimulated with 10 ng/mL with IC50 of approximately 10 nM. GW2580 also inhibits TRKA activity with IC50 of 0.88 μM.