JNJ-28312141 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 885692-52-4 | Cat. No. | BCP28018 |
| Name | JNJ-28312141 | ||
| Synonyms | JNJ28312141; JNJ 28312141; | ||
| SMILES | CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4 | ||
| Chemical Name | |||
| Formula | C26H32N6O2 | M. Wt | 460.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM; shows narrow kinase selectivity profile, also potently inhibits KIT (IC50=5 nM), AXL (12 nM), TRKA (15 nM), FLT3 (30 nM), and LCK (88 nM); inhibits CSF-1-induced CSF-1R phosphorylation with IC50 of 5 nM, inhibits CSF-1-dependent proliferation of mouse macrophages and CSF-1-induced expression of MCP-1 by human monocytes with IC50 of 3 nM; inhibits the ITD-FLT3-dependent proliferation of MV-4-11 cells with IC50 of 21 nM, inhibits FLT3 ligand-induced FLT3 phosphorylation in recombinant Baf3 cells with IC50 of 76 nM; demonstrates potential therapeutic activity in AML, solid tumors and bone metastases in vivo. | ||
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