QS11
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CAS No. | 944328-88-5 | Cat. No. | BCP02472 |
Name | QS11 | ||
Synonyms | QS-11;QS 11;Wnt Synergist; | ||
SMILES | |||
Chemical Name | |||
Formula | C36H33N5O2 | M. Wt | 567.68 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Wnt Synergist, QS11 is a cell-permeable purine compound that binds GTPase activating proteins of ADP-ribosylation factor (ARFGAPs), including AMAP1 (Kd = 364 nM) and ARFGAP1 (Kd = 620 nM) and acts as a broad specificity ARFGAP1 inhibitor. Wnt Synergist, QS11 has also been reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 μM). |
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