Rabusertib New
Data Sheet
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| CAS No. | 911222-45-2 | Cat. No. | BCP02497 |
| Name | Rabusertib | ||
| Synonyms | IC-83;LY 2603618;LY-2603618;LY2603618; | ||
| SMILES | CC1=C(Br)C=C(C(OC[C@@H]2CNCCO2)=C1)NC(NC3=NC=C(N=C3)C)=O | ||
| Chemical Name | |||
| Formula | C18H22BrN5O3 | M. Wt | 436.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types. | ||
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