Vemurafenib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP43160CAS No. ：1029872-54-5Purity：98%

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CAS No.	1029872-54-5	Cat. No.	BCP43160
Related Products	918504-65-1（Vemurafenib）
Name	Vemurafenib
Synonyms	PLX4032;PLX-4032;PLX 4032;
SMILES	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F
Chemical Name
Formula	C23H18ClF2N3O3S	M. Wt	489.92
Purity	98%	Storage	Store at 4-8°C
Description	Vemurafenib is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers.