Rineterkib hydrochloride New
Data Sheet
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| CAS No. | 1715025-34-5 | Cat. No. | BCP43938 |
| Name | Rineterkib hydrochloride | ||
| Synonyms | LTT-462 HCl;LTT 462 HCl;LTT462 HCl;ERK-IN-1; | ||
| SMILES | CNCC(C1=CC(=CC(=C1)Br)F)NC(=O)C2=C(C=C(C=C2)C3=NC(=CN=C3N)C4CCC(C(C4)F)O)F.Cl | ||
| Chemical Name | |||
| Formula | C26H28BrClF3N5O2 | M. Wt | 614.9 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. | ||
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