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Encorafenib Chemical Structure

Encorafenib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP44104CAS No. ：1269440-29-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1269440-29-0 Cat. No. BCP44104
Name Encorafenib
Synonyms LGX818; LGX-818; LGX 818;
SMILES CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC
Chemical Name
Formula C22H27ClFN7O4S M. Wt 540.01
Purity 98% Storage Store at 4-8°C
Description Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.
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