PF-04880594
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 1111636-35-1 | Cat. No. | BCP21016 |
| Name | PF-04880594 | ||
| Synonyms | PF04880594; PF 04880594; | ||
| SMILES | N#CCCNC1=NC=CC(C2=CN(CC(F)F)N=C2C3=CN=C(NC=C4)C4=C3)=N1 | ||
| Chemical Name | |||
| Formula | C19H16F2N8 | M. Wt | 394.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. The combination treatment with PF-04880594 and MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers. | ||
Recommend Products
More >
-
Exarafenib
Cat. No.：BCP49200
No.：2639957-39-2
Product Details -
-
Encorafenib
Cat. No.：BCP44104
No.：1269440-29-0
Product Details -
Rineterkib hydrochloride
Cat. No.：BCP43938
No.：1715025-34-5
Product Details -
-
Vemurafenib
Cat. No.：BCP43160
No.：1029872-54-5
Product Details -
Lifirafenib
Cat. No.：BCP42783
No.：1446090-79-4
Product Details -
Rineterkib
Cat. No.：BCP38204
No.：1715025-32-3
Product Details -
Donafenib
Cat. No.：BCP34023
No.：1130115-44-4
Product Details -
-
Belvarafenib
Cat. No.：BCP31233
No.：1446113-23-0
Product Details -
-
-
B-Raf inhibitor 1 dihydrochloride
Cat. No.：BCP29713
No.：1191385-19-9
Product Details -
Takeda-6d
Cat. No.：BCP29579
No.：1125632-93-0
Product Details -
-
-
B-Raf-IN-1
Cat. No.：BCP28151
No.：950736-05-7
Product Details -
Vemurafenib-Analog
Cat. No.：BCP27823
No.：918505-61-0
Product Details -
Tags:PF-04880594 supplier,PF-04880594 purchase,PF-04880594 manufacturer,PF-04880594 distributor,PF-04880594 cost,PF-04880594 buy,PF-04880594 for sale