MK-2206 2HCl
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS No. | 1032350-13-2 | Cat. No. | BCP01821 |
Related Products | 1032349-93-1(MK-2206) | ||
Name | MK-2206 2HCl | ||
Synonyms | MK2206;MK 2206; | ||
SMILES | |||
Chemical Name | |||
Formula | C25H23Cl2N5O | M. Wt | 480.39 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. |
Recommend Products
More >-
Solenopsin HCl
Cat. No.:BCP49141
No.:137119-46-1
Product Details -
Solenopsin
Cat. No.:BCP48761
No.:137038-57-4
Product Details -
ONC-201 Dihydrochloride
Cat. No.:BCP46830
No.:1638178-82-1
Product Details -
(E)-Akt inhibitor-IV
Cat. No.:BCP46776
No.:959841-49-7
Product Details -
A674563 HCl
Cat. No.:BCP46680
No.:A674563HCl
Product Details -
Borussertib
Cat. No.:BCP43065
No.:1800070-77-2
Product Details -
-
Merck-22-6
Cat. No.:BCP36078
No.:612847-42-4
Product Details -
-
Recilisib sodium
Cat. No.:BCP35048
No.:922139-31-9
Product Details -
E-Guggulsterone
Cat. No.:BCP34834
No.:39025-24-6
Product Details -
-
AT7867 dihydrochloride
Cat. No.:BCP30936
No.:1431697-86-7
Product Details -
-
Miransertib HCl
Cat. No.:BCP25709
No.:1313883-00-9
Product Details -
-
Ipatasertib dihydrochloride
Cat. No.:BCP23821
No.:1396257-94-5
Product Details -
-
Akt Inhibitor IV
Cat. No.:BCP22722
No.:681281-88-9
Product Details -
(Z)-Guggulsterone
Cat. No.:BCP07472
No.:39025-23-5
Product Details
Tags:MK-2206 2HCl supplier,MK-2206 2HCl purchase,MK-2206 2HCl manufacturer,MK-2206 2HCl distributor,MK-2206 2HCl cost,MK-2206 2HCl buy,MK-2206 2HCl for sale