Debio 0932 New
Data Sheet
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| CAS No. | 1061318-81-7 | Cat. No. | BCP27980 |
| Name | Debio 0932 | ||
| Synonyms | Debio0932; Debio-0932; CUDC305; CUDC-305; CUDC 305; | ||
| SMILES | CC(C)(C)CNCCN1C2=C(C(=NC=C2)N)N=C1SC3=CC4=C(C=C3N(C)C)OCO4 | ||
| Chemical Name | |||
| Formula | C22H30N6O2S | M. Wt | 442.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. | ||
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