Shepherdin New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP42633CAS No. ：861224-28-4Purity：98%

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CAS No.	861224-28-4	Cat. No.	BCP42633
Name	Shepherdin
Synonyms	NSC-741765; NSC741765; NSC 741765;
SMILES	CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(=O)O)C(C)(C)C)NC(=O)C(CS)NC(=O)CNC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)N
Chemical Name
Formula	C41H64N12O12S	M. Wt	949.09
Purity	98%	Storage	Store at 4-8°C
Description	Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.Shepherdin 79-87 is amino acids 79 to 87 fragment of Shepherdin. Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms. Conversely, shepherdin does not reduce the viability of normal cells nor affect colony formation of purified hematopoietic progenitors. Systemic administration of shepherdin in vivo is well tolerated, and inhibits human tumor growth in mice without toxicity.