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Raltitrexed Chemical Structure

Raltitrexed

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02874CAS No. :112887-68-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 112887-68-0 Cat. No. BCP02874
Name Raltitrexed
Synonyms TDX;ZD 1694;ZD1694;ZD-1694;Tomudex;D1694; ICID1694; D-1694; ICID-1694; D 1694; ICID 1694;;
SMILES
Chemical Name
Formula C21H22N4O6S M. Wt 458.49
Purity 98% Storage Store at 4-8°C
Description Raltitrexed (Tomudex) is an antimetabolite drug used in cancer chemotherapy. Raltitrexed (Tomudex) is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting Dihydrofolate reductase, an enzyme used in the synthesis of tetrahydrofolate, thereby preventing the synthesis of thymidylate.In a study, there was an inverse relationship between reduced folate cellular content and raltitrexed IC50; this relationship did not, however, reach statistical significance. The only significant relationship was found between basal cellular folylpolyglutamate synthetase activity and raltitrexed IC50r = -0.56, p = 0.03. Tumor cells with a relatively high folylpolyglutamate synthetase activity were more sensitive to raltitrexed cytotoxic effects and vice versa.
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