LY2334737

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP17137CAS No. ：892128-60-8Purity：98%

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CAS No.	892128-60-8	Cat. No.	BCP17137
Name	LY2334737
Synonyms	LY-2334737;LY 2334737;
SMILES
Chemical Name
Formula	C17H25F2N3O5	M. Wt	389.39
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Five cell lines that express CES2 responded to LY2334737treatment. LY2334737 was less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. The drug response of CES2-transfected HCT-116 cells correlated with CES2 expression level. Bystander studies showed statistically greater PC-3-GFP growth inhibition by LY2334737 when cells were cocultured with CES2 and not mock transfectants. in vivo: Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days showed greater tumor growth inhibition of CES2 transfectant than the mock transfectant (P ≤ 0.001) . The MTD was 40 mg LY2334737. Fatigue was the most frequent DLT for LY2334737monotherapy (4 patients) followed by elevated transaminase levels (2 patients), both observed at the 40- to 50-mg dose levels. Among the 10 patients in the combination arm, 2 had DLTs at the 40-mg dose level. These were fatigue and elevated liver enzyme levels. Metronomic LY2334737 administration caused increased blood flow in luci