PF4800567
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1188296-52-7 | Cat. No. | BCP28458 |
| Name | PF4800567 | ||
| Synonyms | PF 4800567; PF-4800567; | ||
| SMILES | NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1 | ||
| Chemical Name | |||
| Formula | C17H18ClN5O2 | M. Wt | 359.81 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-4800567 is a selective, ATP competitive casein kinase 1ε inhibitor with IC50 values of 32 and 711 nM for CK1ε and CK1δ respectively. Casein kinase 1 epsilon (CK1epsilon) and casein kinase 1 delta (CK1delta) are closely related Ser-Thr protein kinases that serve as key clock regulators as demonstrated by mammalian mutations in each that dramatically alter the circadian period. PF-4800567 displays 22-fold greater potency towards CK1ε than CK1δ. PF-4800567 completely blocks CK1epsilon-mediated PER3 nuclear localization and PER2 degradation. | ||
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