D4476
Data Sheet
For research use only. Not for human use.
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| CAS No. | 301836-43-1 | Cat. No. | BCP09776 |
| Name | D4476 | ||
| Synonyms | Casein Kinase I Inhibitor;D 4476;D-4476; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H18N4O3 | M. Wt | 398.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | D4476 is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested, including Akt1 (PKB), SGK and GSK-3b. D4476 may either inhibit or foster apoptosis. D4476 inhibits nuclear export of eIF6 and results in nuclear accumulation of eIF6. In HeLa cells D4476 has been used to inhibit CK-1 phosphorylation of RhoB but not RhoA or RhoC activating RhoB dependent actin fiber formation. D4476 has been observed to block the Wnt-3a-induced phosphorylation and shift in electrophoretic migration of Dvl-1(dishevelled, Dvl). | ||
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