PF-5006739
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1293395-67-1 | Cat. No. | BCP29752 |
| Name | PF-5006739 | ||
| Synonyms | PF 5006739; PF5006739; | ||
| SMILES | C1CN(CCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F)CC5=NOC=C5 | ||
| Chemical Name | |||
| Formula | C22H22FN7O | M. Wt | 419.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-5006739 is a Potent CK1δ/ε inhibitor. PF-5006739 attenuates opioid drug-seeking behavior. PF-5006739 possesses a desirable profile, with low nanomolar in vitro potency for CK1δ/ε (IC50 = 3.9 and 17.0 nM, respectively) and high kinome selectivity. In vivo, PF-5006739 demonstrated robust centrally mediated circadian rhythm phase-delaying effects in both nocturnal and diurnal animal models. Further, PF-5006739 dose-dependently attenuated opioid drug-seeking behavior in a rodent operant reinstatement model in animals trained to self-administer fentanyl. | ||
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