Silmitasertib sodium New
Data Sheet
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| CAS No. | 1309357-15-0 | Cat. No. | BCP38774 |
| Name | Silmitasertib sodium | ||
| Synonyms | Silmitasertib sodium salt;CX-4945 sodium salt;CX4945 Sodium; | ||
| SMILES | C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)[O-])C4=C2C=CN=C4.[Na+] | ||
| Chemical Name | |||
| Formula | C19H11ClN3NaO2 | M. Wt | 371.75 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Silmitasertib Sodium is the sodium salt of silmitasertib, an orally bioavailable small-molecule inhibitor of CK2 with potential antineoplastic activity. Silmitasertib selectively binds to and inhibits the enzyme casein kinase II (CK2), which may lead to an inhibition of cellular proliferation. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. CK2 regulates a diverse array of pro-survival cellular processes including epidermal growth factor receptor (EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling, Hsp90 machinery, hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the activity of XRCC1 and MDC1, two mediator/adaptor proteins that are essential for DNA repair. | ||
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