Upamostat New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP46045CAS No. ：1191101-18-4Purity：98%

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CAS No.	1191101-18-4	Cat. No.	BCP46045
Name	Upamostat
Synonyms	WX 671; WX671; WX-671;Mesupron;
SMILES	CCOC(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=NO)N)NS(=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C
Chemical Name
Formula	C32H47N5O6S	M. Wt	629.81
Purity	98%	Storage	Store at 4-8°C
Description	Upamostat is an orally bioavailable, 3-amidinophenylalanine-derived, second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. After oral administration, upamostat is converted to the active N alpha-(2,4,6-triisopropylphenylsulfonyl)-3-amidino-(L)-phenylalanine-4-ethoxycarbonylpiperazide (WX-UK1), which inhibits several serine proteases, particularly uPA; inhibition of uPA may result in the inhibition of tumor growth and metastasis. uPA is a serine protease involved in degradation of the extracellular matrix and tumor cell migration and proliferation.