UK-371804 hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 256476-36-5 | Cat. No. | BCP29661 |
| Name | UK-371804 hydrochloride | ||
| Synonyms | UK 371804 HCl；UK-371804 HCl；UK371804 HCl；UK 371804 hydrochloride；UK371804 hydrochloride; | ||
| SMILES | CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl | ||
| Chemical Name | |||
| Formula | C14H17Cl2N5O4S | M. Wt | 422.29 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. UK-371804 was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers. | ||
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