Indophagolin New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP41936CAS No. ：1207660-00-1Purity：98%

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Chemical Properties&Biological Activity

CAS No.	1207660-00-1	Cat. No.	BCP41936
Name	Indophagolin
Synonyms	HIT ID;
SMILES	C1CC1C(=O)N2CCC3=CC(=C(C=C32)S(=O)(=O)NC4=CC(=C(C=C4)Cl)C(F)(F)F)Br
Chemical Name
Formula	C19H15BrClF3N2O3S	M. Wt	523.75
Purity	98%	Storage	Store at 4-8°C
Description	Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.

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