SBP-7455 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1884222-74-5 | Cat. No. | BCP48924 |
| Name | SBP-7455 | ||
| Synonyms | SBP7455; SBP 7455; | ||
| SMILES | COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC | ||
| Chemical Name | |||
| Formula | C16H17F3N4O2 | M. Wt | 354.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SBP-7455 is a dual inhibitors of ULK1 and ULK2 (ULK1/2). It displayed improved binding affinity for ULK1/2 compared with SBI-0206965, potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. SBP-7455 inhibited starvation-induced autophagic flux in TNBC cells. | ||
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