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PSEM 89S TFA Chemical Structure

PSEM 89S TFA

Data Sheet For research use only. Not for human use.
Cat. No. :BCP35173CAS No. :1336913-03-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1336913-03-1 Cat. No. BCP35173
Name PSEM 89S TFA
Synonyms PSEM 89S;
SMILES COC1=CC(=C(C=C1)OC)C(=O)NC2CN3CCC2CC3.C(=O)(C(F)(F)F)O
Chemical Name
Formula C18H23F3N2O5 M. Wt 404.39
Purity 98% Storage Store at 4-8°C
Description PSEM 89S TFA is a PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.
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