PF-06459988 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1428774-45-1 | Cat. No. | BCP44108 |
| Name | PF-06459988 | ||
| Synonyms | PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988; | ||
| SMILES | CN1C=C(C=N1)NC2=NC3=C(C(=CN3)Cl)C(=N2)OCC4CN(CC4OC)C(=O)C=C | ||
| Chemical Name | |||
| Formula | C19H22ClN7O3 | M. Wt | 431.88 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance. | ||
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