Befotertinib New
Data Sheet
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| CAS No. | 1835667-63-4 | Cat. No. | BCP49575 |
| Name | Befotertinib | ||
| Synonyms | D-0316;D0316;D 0316; | ||
| SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)CC(F)(F)F)OC | ||
| Chemical Name | |||
| Formula | C29H32F3N7O2 | M. Wt | 567.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Befotertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, befotertinib specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, befotertinib may have therapeutic benefits in tumors with T790M-mediated drug resistance. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. | ||
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