Almonertinib New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1899921-05-1 | Cat. No. | BCP38312 |
| Related Products | 2134096-03-8（Almonertinib hydrochloride） 2134096-06-1（Almonertinib mesylate） | ||
| Name | Almonertinib | ||
| Synonyms | HS-10296; HS 10296; HS10296; | ||
| SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC | ||
| Chemical Name | |||
| Formula | C30H35N7O2 | M. Wt | 525.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Almonertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. | ||
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