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CB-839 Chemical Structure

CB-839

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP28287CAS No. ：1439399-58-2Purity：98%
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  • Publications Citing of Biochempartner's CB-839
J Control Release . 2022 Aug 13;350:1-10.
  • Chemical Properties&Biological Activity
CAS No. 1439399-58-2 Cat. No. BCP28287
Name CB-839
Synonyms CB839; CB 839；Telaglenastat,;
SMILES O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
Chemical Name
Formula C26H24F3N7O3S M. Wt 571.57
Purity 98% Storage Store at 4-8°C
Description CB-839 is an orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. CB-839 selectively and irreversibly inhibits glutaminase. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.
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