SH-4-54
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1456632-40-8 | Cat. No. | BCP28211 |
| Name | SH-4-54 | ||
| Synonyms | SH 4-54; SH4-54; SH-454; SH 454; SH454; | ||
| SMILES | O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1 | ||
| Chemical Name | |||
| Formula | C29H27F5N2O5S | M. Wt | 621.17 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations. Moreover, in vivo,SH-4-54 exhibited blood-brain barrier permeability, potently controlled glioma tumor growth, and inhibited pSTAT3 in vivo. | ||
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