XL139 mesylate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | XL139 | Cat. No. | BCP23569 |
| Name | XL139 mesylate | ||
| Synonyms | BMS833923; BMS-833923; BMS 833923; XL139; XL-139; XL 139; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C32H35N5O7S2 | M. Wt | 665.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers. | ||
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