GSA10

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP24130CAS No. ：300833-95-8Purity：98%

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CAS No.	300833-95-8	Cat. No.	BCP24130
Name	GSA10
Synonyms	GSA 10; GSA-10;
SMILES	O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(N(CCCCCC)C2=O)C=CC=C3)=O)C=C1
Chemical Name
Formula	C26H30N2O4	M. Wt	434.54
Purity	98%	Storage	Store at 4-8°C
Description	GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). GSA-10 fits to the agonist pharmacophoric model with two hydrogen bond acceptor groups and four hydrophobic regions. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 does not recognize the classic bodipy-cyclopamine binding site. GSA-10 allows the pharmacological characterization of a novel Smo active site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and cholera toxin. GSA-10 belongs to a new class of Smo agonists and will be helpful for dissecting Hh mechanism of action, with important implications in physiology and in therapy.