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Saridegib Chemical Structure

Saridegib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP25392CAS No. ：1037210-93-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1037210-93-7 Cat. No. BCP25392
Name Saridegib
Synonyms IPI 926; IPI-926; IPI926;Patidegip;
SMILES CC1CC2C(C(C3(O2)CCC4C5CCC6CC(CCC6(C5CC4=C(C3)C)C)NS(=O)(=O)C)C)NC1
Chemical Name
Formula C29H48N2O3S M. Wt 504.77
Purity 98% Storage Store at 4-8°C
Description Saridegib, also known as IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.
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