GSK3145095 New
Data Sheet
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| CAS No. | 1622849-43-7 | Cat. No. | BCP31015 |
| Name | GSK3145095 | ||
| Synonyms | GSK-3145095; GSK 3145095; | ||
| SMILES | O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@H]3CCC4=CC(F)=CC(F)=C4NC3=O | ||
| Chemical Name | |||
| Formula | C20H17F2N5O2 | M. Wt | 397.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK3145095 is a potent and orally active RIPK1 inhibitor (IC50 = 5 nM) with potential antineoplastic and immunomodulatory activities. GSK3145095 disrupts RIPK1-mediated signaling, which may reduce C-X-C motif chemokine ligand 1 (CXCL1)-driven recruitment and migration of immunosuppressive myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME). This allows effector cells, such as natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), to kill and eliminate cancer cells. | ||
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