RIPA-56 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1956370-21-0 | Cat. No. | BCP44340 |
| Name | RIPA-56 | ||
| Synonyms | RIPA56; RIPA 56; | ||
| SMILES | CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O | ||
| Chemical Name | |||
| Formula | C13H19NO2 | M. Wt | 221.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RIPA-56 is a potent RIP1 inhibitor. RIPA-56 has RIP1 kinase IC50=13 nM; HT-29 Cell EC50 = 28 nM; in vivo PG: t1/2 = 3.1h. RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multiorgan damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies. | ||
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