Necrostatin-34 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 375835-43-1 | Cat. No. | BCP44627 |
| Name | Necrostatin-34 | ||
| Synonyms | Nec-34; | ||
| SMILES | CC1=CC=C(C=C1)C2CC(=O)NC(=C2C#N)SCC(=O)NC3=NC=CS3 | ||
| Chemical Name | |||
| Formula | C18H16N4O2S2 | M. Wt | 384.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Necrostatin-34 exhibits IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively.Necrostatin-34 inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation.Necrostatin-34 may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase. | ||
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