GSK-963 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2049868-46-2 | Cat. No. | BCP37994 |
| Name | GSK-963 | ||
| Synonyms | GSK 963; GSK963; | ||
| SMILES | CC(C)(C)C(=O)N1C(CC=N1)C2=CC=CC=C2 | ||
| Chemical Name | |||
| Formula | C14H18N2O | M. Wt | 230.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK-963 is a potent and selective inhibitor of RIP1 kinase. GSK'963 is significantly more potent than Nec-1 in both biochemical and cellular assays, inhibiting RIP1-dependent cell death with an IC50 of between 1 and 4 nM in human and murine cells. GSK'963 is >10 000-fold selective for RIP1 over 339 other kinases, lacks measurable activity against IDO and has an inactive enantiomer, GSK'962, which can be used to confirm on-target effects. | ||
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