Eclitasertib New
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| CAS No. | 2125450-76-0 | Cat. No. | BCP48186 |
| Name | Eclitasertib | ||
| Synonyms | Eclitasertibum; | ||
| SMILES | CN1C(=O)C(COC2=C1N=CC=C2)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4 | ||
| Chemical Name | |||
| Formula | C19H18N6O3 | M. Wt | 378.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Eclitasertib is an orally bioavailable, small-molecule inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1; receptor-interacting protein 1; RIP1), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, eclitasertib disrupts RIPK1-mediated signaling, and may attenuate inflammation and the resulting tissue damage. RIPK1, a signaling protein in the tumor necrosis factor (TNF) receptor pathway, plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition. | ||
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