LYN-1604

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP28888CAS No. ：2088939-99-3Purity：98%

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CAS No.	2088939-99-3	Cat. No.	BCP28888
Related Products	LYN-1604HLC（LYN-1604 hydrochloride） 2310109-38-5（LYN-1604 dihydrochloride）
Name	LYN-1604
Synonyms	LYN 1604; LYN1604;
SMILES
Chemical Name
Formula	C33H43Cl2N3O2	M. Wt	584.62
Purity	98%	Storage	Store at 4-8°C
Description	LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo; thus making this ULK1 agonist a novel potential small-molecule drug candidate for future TNBC therapy.