Ixazomib Citrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1201902-80-8 | Cat. No. | BCP02411 |
| Name | Ixazomib Citrate | ||
| Synonyms | MLN-9708;MLN9708;MLN 9708; | ||
| SMILES | B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl | ||
| Chemical Name | |||
| Formula | C20H23BCl2N2O9 | M. Wt | 517.12 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MLN9708 is a selective, orally bioavailable, second-generation proteasome inhibitor. MLN9708 has a shorter proteasome dissociation half-life and improved pharmacokinetics, pharmacodynamics, and antitumor activity compared with bortezomib, which we believe plays an important role in its improved tissue distribution. MLN9708 has a larger blood volume distribution at steady state, and analysis of 20S proteasome inhibition and markers of the unfolded protein response confirms that MLN9708 has greater pharmacodynamic effects in tissues than bortezomib. MLN9708 is a second-generation small-molecule proteasome inhibitor being developed for the treatment of a broad range of human malignancies.Upon exposure to aqueous solutions or plasma, MLN9708 rapidly hydrolyzes to its biologically active form MLN2238.MLN2238 is the biologically active form of MLN9708. | ||
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