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Calpain Inhibitor XII Chemical Structure

Calpain Inhibitor XII

Data Sheet For research use only. Not for human use.
Cat. No. :BCP40190CAS No. :181769-57-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 181769-57-3 Cat. No. BCP40190
Name Calpain Inhibitor XII
Synonyms (Rac)-Calpain Inhibitor XII;
SMILES CCCC(C(=O)C(=O)NCC1=CC=CC=N1)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2
Chemical Name
Formula C26H34N4O5 M. Wt 482.57
Purity 98% Storage Store at 4-8°C
Description Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
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