![Epoxomicin Chemical Structure Epoxomicin Chemical Structure](https://img.biochemsafebuy.com/uploads/img/134381-21-8_BCP13740.png)
Epoxomicin New
![](/templates/admin/Portal/site5/assets/images/ziliao.png)
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
![](/templates/admin/Portal/site5/assets/images/wxggyw.png)
CAS No. | 134381-21-8 | Cat. No. | BCP13740 |
Name | Epoxomicin | ||
Synonyms | BU-4061T; | ||
SMILES | O=C([C@@H](NC([C@H]([C@@H](C)O)NC([C@@H](NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)[C@@]1(C)CO1 | ||
Chemical Name | |||
Formula | C28H50N4O7 | M. Wt | 554.72 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM. By inhibiting osteoblast proteasome activity, epoxomicin stimulates bone formation at concentrations as low as 10 nM. Intraperitoneal injection of 1.5 mg/kg epoxomicin given daily for two weeks induces Parkinson's-like symptoms in rats and addition of 100 nM epoxomicin to rat ventral midbrain cultures results in apoptosis specific to dopaminergic neurons. Epoxomicin-induced parkinsonism can be a useful model to examine mechanisms and therapies for the disease. |
Recommend Products
More >![](https://www.biochempartner.com/templates/admin/Portal/site5/assets/images/arrow-fl.png)
-
-
-
Calpain Inhibitor XII
Cat. No.:BCP40190
No.:181769-57-3
Product Details -
-
-
Ixazomib citrate
Cat. No.:BCP16600
No.:1239908-20-3
Product Details -
-
-
-
Gabexate mesylate
Cat. No.:BCP13557
No.:56974-61-9
Product Details -
Lactacystin
Cat. No.:BCP13243
No.:133343-34-7
Product Details -
-
Cysteine Protease inhibitor
Cat. No.:BCP11075
No.:921625-62-9
Product Details -
(R)-MG-132
Cat. No.:BCP28290
No.:1211877-36-9
Product Details -
18α-Glycyrrhetinic acid
Cat. No.:BCP09996
No.:1449-05-4
Product Details -
-
Ixazomib Citrate
Cat. No.:BCP02411
No.:1201902-80-8
Product Details -
-
-
![](/templates/admin/Portal/site5/assets/images/arrow-fr.png)
Tags:Epoxomicin supplier,Epoxomicin purchase,Epoxomicin manufacturer,Epoxomicin distributor,Epoxomicin cost,Epoxomicin buy,Epoxomicin for sale