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MarizoMib Chemical Structure

MarizoMib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP13082CAS No. :437742-34-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 437742-34-2 Cat. No. BCP13082
Name MarizoMib
Synonyms ML 858; ML-858; ML858; NPI 0052; NPI-0052; NPI0052; (-)-Salinosporamide A; Salinosporamide A;
SMILES CC12C(C(=O)NC1(C(=O)O2)C(C3CCCC=C3)O)CCCl
Chemical Name
Formula C15H20ClNO4 M. Wt 313.78
Purity 98% Storage Store at 4-8°C
Description Marizomib, also known as ML 858, NPI-0052 and Salinosporamide A, is a potent and selective 20S proteasome inhibitor from natural origin. Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients. Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier. Marizomib exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.
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