SR 12813 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 126411-39-0 | Cat. No. | BCP25726 |
| Name | SR 12813 | ||
| Synonyms | SR-12813;SR12813;GW 485801;GW-485801;GW485801; | ||
| SMILES | OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C | ||
| Chemical Name | |||
| Formula | C24H42O7P2 | M. Wt | 504.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SR12813 is a potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR; only shows weak activition for rat and mouse PXR; inhibits cholesterol synthesis (IC50=1.2 uM) with no effect on fatty acid synthesis, reduces cellular HMG-CoA reductase activity with IC50 of 0.85 uM; induce CYP3A expression in primary hepatocytes. | ||
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