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Rosuvastatin Chemical Structure

Rosuvastatin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02356CAS No. :287714-41-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 287714-41-4 Cat. No. BCP02356
Name Rosuvastatin
Synonyms S-4522; S 4522; S4522; ZD 4522;ZD-4522;ZD4522;X-Plended;Crestor;
SMILES
Chemical Name
Formula C22H28FN3O6S M. Wt 481.54
Purity 98% Storage Store at 4-8°C
Description in vitro: Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM . Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin . Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells . in vivo: Rosuvastatin (3 mg/kg) daily administration for 14 days decreases plasma cholesterol levels by 26% in male beagle dogs with normal cholesterol levels. In cynomolgus monkeys, Rosuvastatin decreases plasma cholesterol levels by 22% . R
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