Rosuvastatin Calcium
Data Sheet
For research use only. Not for human use.
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| CAS No. | 147098-20-2 | Cat. No. | BCP04131 |
| Name | Rosuvastatin Calcium | ||
| Synonyms | S-4522; S 4522; S4522; ZD 4522; ZD-4522; ZD4522; ZD 4522 calcium salt;Rosuvastatin hemicalcium; ZD 4522 Calcium;CRESTOR;Rosuvastatin Calcium Salt; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | 2(C22H27FN3O6S).Ca | M. Wt | 1001.14 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM.Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin. Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells. | ||
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