S49076 HCl New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP35053CAS No. ：1265965-19-2Purity：98%

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CAS No.	1265965-19-2	Cat. No.	BCP35053
Name	S49076 HCl
Synonyms	S49076 Hydrochloride;S 49076 HCl;S-49076 HCl;
SMILES	C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl
Chemical Name
Formula	C22H23ClN4O4S	M. Wt	474.96
Purity	98%	Storage	Store at 4-8°C
Description	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. MET, AXL, and the FGFRs have all been implicated in resistance to VEGF/VEGFR inhibitors such as bevacizumab. A phase I study with S-49076 is currently underway in patients with advanced solid tumors.